I'm in a daily h2h standard league and found that using middle relievers has been enormously effective.
My two "aces" are Archer and Tanaka (luckily I also have Bundy and Stripling).
If I'm a little light on K's for my weekly matchup then I just stream. On paper my staff looks sucky but I've actually had one of the best performing staffs in the league. By rostering six middle relievers I am top 3 in my league in: ERA, WHIP, Wins, and I am top 5 in Strikeouts.
My offense has been pretty good because I spent almost all of my high draft picks on hitters. Thought I would try it this year but I've been surprised that it's worked THIS well.