Considering facing Boston in Boston normally *most* would sit unless their pitcher is an ace. This year so far is a little different, considering the Red Sox have really struggled coming out of the gate.
What is interesting too me is, if you're a fan of Fan Graphs and advance stats (*most around here are big fans) I'm not sure you would even consider sitting Boyd. Though early, Boyd's advance stats suggest Boyd is a very good pitcher right now. Boyd's ERA is 2.96, fip is 1.65. and xfip is 2.60. Oh his siera is 2.83, BABIP is .345 and swstr% is 16.1.
Are you chasing the talent, or the matchup?
I'll be honest, I will probably end up benching Boyd, and have no really good argument why, besides I think Sale is going to have a monster game soon, showing the baseball world nothing major is wrong with him. And see, that argument isn't a very good one, and has nothing to do with Boyd.